Unlocking the Antidiabetic Potential of Quercetin

Bhoj Raj¹, Manjusha Choudhary², Vikas Budhwar¹*

¹Department of Pharmaceutical Science, MDU, Rohtak, Haryana, India.

²Institute of Pharmaceutical Sciences KU, Kurukshetra, Haryana, India.

*Corresponding Author E-mail: drvikasbudhwar@mdurohtak.ac.in

ABSTRACT:

The major supply of energy is the body, glucose, is necessary. Still, excessive blood sugar can cause other major problems, such as impairments to the kidneys, eyesight, and cardiovascular system. Hyperglycemia is the term used to describe the condition in which blood sugar levels are important. DM is a metabolic disease that induces hyperglycemia and has been linked to many deaths. Therefore, many treatments and preventive measures have been taken to fight DM. Several oral drugs, such as sulfonylureas, metformin, and rosiglitazone, are used to treat diabetes. Some medicines, though, are not suitable for certain populations or carry significant risks. Here, we discuss about the antidiabetic mechanism of the natural compound Quercetin. Also, we discovered that Quercetin possesses anti-inflammatory, anticancer, and anti-allergic properties. It has been noted that anti-allergic stress and the level of inflammation influence the onset of DM. Plant flavonol quercetin possesses biological properties that include anti-inflammatory, anti-cancer, antidiabetic, neuroprotective, and anti-allergic effects.The main objective of this review is to explore the antidiabetic potential of the Quercetin from previously published research on the anti-diabetic act of Quercetin. Overall, For the statistical analysis, 15 qualifying publications with suitable serum glucose data were used. The analysis for serum glucose level (mg/dL) showed a significant difference between the means at doses of 10, 25, and 50mg/kg. Thus, at dose of 10, 25, and 50mg/kg, Quercetin lowers serum glucose levels, according to the analysis's results.

KEYWORDS: Quercetin, Diabetes mellitus, hyperglycemia, antidiabetic activity.

1. INTRODUCTION: 

Diabetes mellitus is a serious worldwide medical condition described by high blood sugar levels, which is caused by a single cell-level a restriction of insulin or a complete or relative lack of insulin. The most noticeable illness is types-II diabetes mellitus (T2DM), which account for 90–95% of diabetic patients¹. Glucose bias, elevated serum glucose levels during fasting and after meals, tissue insensitivity to insulin, reduced insulin release, and obesity are the main characteristics of type 2 diabetes.

Diabetic conditions, particularly those with inadequate glucose regulation, can lead to hazardous disorientation². Expanded creation of receptive oxygen species (ROS) and disabled cell reinforcement safeguard are the fundamental atomic components that upgrade oxidative pressure (operating system) in diabetes. Different confirmations have shown an elevated degree of free revolutionaries and oxidative pressure biomarkers in tissue tests of diabetic patients³. The primary cause of the extreme presence of operating system biomarkers and free revolutionaries in diabetes is hyperglycemia, which leads to an excess of ROS produced by the mitochondria⁴. DNA, lipids, and other cellular macromolecules can be harmed by ROS, which include O₂, OH, and H₂O₂⁵. The pathophysiology of many diseases is aided by the four fundamental mechanisms of DNA damage, aggravation, film lipid peroxidation, and protein oxidation. These mechanisms diminish the counterparts of the cell free radical-induced OS⁶.

Natural medications have been ensured in constant problems of treatment both in the created and agricultural nations among individuals and researchers working nearby⁷.

Because of its natural mobility and wide availability in dietary sources, Quercetin is a nutritional flavonoid that has been regarded by reputable researchers as fundamentally important. About 75% of our total flavonoid intake comes from the Quercetin can consume on a daily basis.

Quercetin is found in fruits, vegetables, and other plant-based foods as Quercetin aglycon, a glycoside conjugated to glucose or other sugar moieties⁸. Plants contain, for instance, quercetin-3-rhamnoglucoside, a glycoside derivative of Quercetin⁹.

Quercetin is a natural going on flavonoid that is present in a large range of fruits and vegetables. It is also referred to as 3,3',4',5,7-pentahydroxyflavone. It was uncovered to contain a few useful impacts on wellbeing, consolidating antibacterial, antiviral, hostile to corpulence, cell reinforcement, anticarcinogenic, and mitigating effects¹⁰.

Every one of these perceptions suggests that the chloroform concentrate of products of cucumber could be viewed as a good anti ulcerate, which could be credited to its substance of flavonoid and mucilage. A few minutes after food enters the stomach, the stomach is ignored for 15 to 25 seconds by delicate, peristaltic developments that bring blending waves.. These waves macerate food, blend it in with emissions from gastric organs, and decrease it to a soupy fluid called chime¹¹.

For example, A number of plants, including Cuscuta reflexa, Curcuma domestica valeton, Daucus carota, Glycyrrhiza glabra, Emblica officinalis, and Foeniculum vulgare It is known that the following plants can prevent cancer: Mangifera indica, Momordica charantia, Ocimum sanctum, Psoralea corylifolia, Santalum collection, Solanum nigrum, Swertia chirayita, and Withania somnifera.^12,13.

One of the important bioflavonoids found in more than twenty plant materials is Quercetin. [Table 1], and it is known for its mitigating, antihypertensive, vasodilator impacts, antiobesity, antihypercholesterolemic, and antiatherosclerotic effects ^14,15. Free-extremism is one of the critical variables for the improvement of infections like hypertension, vascular issues, and metabolic conditions. Sickness brought about by free radicals and oxidants is summed up in Table 2. This survey aims to collect information on the pharmacological and natural significance of the bioactive flavonoid Quercetin.

Table 1: Source of Quercetin

S. No.	Plant name	Family	Geographical source	Ethno-botanical uses
1	Camellia	Theaceae	Southeast Asia	Analgesic, antiviral, antiseptic, antidiabetic, bronchodilator
2	Allium fistulosum	Amaryllidaceae	China	Spring onions as food ingredient
3	Calamus scipionum	Calamoideae	Brunel, Sumatra (Indonesia)	Source of cane
4	Morus alba	Moraceae	China	Diet
5	Moringa oleifera	Moringa	Tropical and Sub-tropical region	Antibacterial, anti-inflammatory antihypertensive,
6	Apium graveolens	Apiaceae	North Africa Europe,Siberia and the Caucasus	Antibacterial, Anti hypertensive, and antidiabetic, Anti-inflammatory
7	Cantella asiatica	Apiaceae	India	As a Wound healing agent
8	Hypericum hircinum	Clusiaceae	Britain	Anti-oxidant
9	Hypericaceae perfortum	Hypericaceae	European countries	Neurological effects, major depressive disorders
10	Brassica oleracea var. Italic(broccoli)	Brassicaceae	Asian and European country	Edible plants, prevent fluid retention or cancer
11	Brassica oleracea var. Sabellica(kale)	Brassicaceae	European country	Neuropathy, anti diabetic, reduce risk of stroke.
12	Coriadrum sativum	Apiaceae	Southern Europe, northern Africa to southwestern Asia	Reduce BP, Cholesterol And  Dyspepsia
13	Lactuca sativa	Asteraceae	Mediterranean, Siberia	Osteoporosis, Iron deficiency anemia
14	Allium cepa	Liliaceae	Italy	Anti-oxidant,, immune stimulation, cardio-protective,
15	Nasturtium officinale	Brassicaceae	Brassicaceae	Anti diabetic, reduce risk of cancer
16	Capparis spinosa	Capparaceae	Europe	Disinfectants, vermifuses
17	Prunus domestica	Rosaceae	North America	Food supplement, laxative

Table 2. Illness brought on by oxidants and free radiation

Human system	Disease
CNS	Stroke, Depression Alzheimer’s
Cardiovascular system	Atherosclerosis, Hypertension, Cardiomyopathy
Repiratory system	Asthma
Excretory system	Rena failure
Skeletal system	Arthritis, rheumatism
Metabolic system	Diabetics
Multiiorgans	Cancer, inflammation aging

1.1 Healthcare and Free-Radical:

The development of physiological sum (low or reasonable centralizations) of free-extremist is fundamental for battle against an ominous climate. To kill harmful bacteria, phagocytes do in fact release free radicals. Nitrogen oxide (NO) and reactive oxygen species (ROS), as well as other free radicals, are crucial regulatory UN armed armed forces in signal processes. Nitrous oxide and reactive oxygen species control vascular tone, oxygen strain, which controls ventilation, and the synthesis of erythropoietin in higher organisms.¹⁶ Nitrogen oxide (NO) and reactive oxygen species (ROS). Oxygen initiates nonenzymatic reactions, whereas the respiratory chain, phagocytosis, prostaglandin synthesis, and the cytochrome P450 system are involved in enzymatic reactions that generate free radicals¹⁷.

1.2 Flavonoids as Antioxidant:

Cell reinforcements restrain the oxidation response of different atoms that can deliver free extremists. These cell reinforcements are normal or engineered supplement which assists with further developing the free extremists instigated neurotic circumstances. Vitamin A, L-ascorbic acid, and Vitamin E are dietary cell reinforcements, usually present in vegetables and natural products which help to repress the free radicals¹⁷. Many plant flavonoids have rich cell reinforcement properties which are utilized for the treatment of fiery issues.

Flavonoids, which come from the Latin word "flavus," which means yellow, are phenolic compounds that have biological properties like being anti-inflammatory, antiviral, anti-allergic, and vasodilating . Flavonoids are for the most part tracked down in natural products, vegetables, and certain refreshments that have adaptable gainful cancer prevention agent impact¹⁸. There are thought to be more than 3000 different types of flavonoids, and they have recently generated a lot of interest due to their possible positive effects on human health, including the treatment of neurodegenerative disorders and potential antiviral, antiallergic, antiplatelet, anti-inflammatory, and antioxidant properties¹⁹. Flavonoids are classified into six classes as indicated by the substance structure into flavonols, flavanols, isoflavones flavones, flavanones, and anthocyanidins²⁰.

2 Quercetin As A Therapeutic Natural Compounds:

Named after the Latin word "Quercetum," quercetin (3,3',4',5,7-pentahydroxyflavone) [Fig.1] indicates that Oaks Woodland is a member of the flavonol class, which the human body is unable to produce²¹. It is yellow tone and is inadequately solvent in steaming hot water, very dissolvable in liquor and lipids and is insoluble in cool water. One of the bioflavonoids most commonly used to treat metabolic and inflammatory conditions is quercetin. Quercetin is viewed as one of the most strong cell reinforcements among other polyphenols, for example, curcumin, resveratrol, kaempferol, and so on²³. Quercetin is a significant flavonoid whose anti-diabetic properties have been investigated. The anti-diabetic effect of Quercetin is confirmed by systematic evaluation and meta-analysis. Quercetin antidiabetic activity brings down serum glucose in a portion subordinate design²⁴.

Fig. 1 Chemical St. of Quercetin ¹³

This dietary flavonoid is potentially one of the most abundant ones found in natural products (mostly citrus), green, lush vegetables, a variety of seeds, nuts, flowers, barks, broccoli, buckwheat, onions, apples, green tea, red grapes, red wine, dull cherries, and fruit like blueberries and cranberries. Flavonols were found in high concentrations in Drinks like tea, vegetables like broccoli and onions, and fruits like apples, cherries, and berries.

Quercetin is a characteristic flavonoid tracked down in many leafy foods. It has a few remedial impacts, including: cancer prevention agent, calming, antiviral, anticancer, and cardiovascular problems. Quercetin is utilized to treat arthritis, allergies, inflammation, cancer, and cardiovascular problems. Quercetin is a characteristic flavonoid tracked down in many leafy foods. It has a few remedial impacts, including: cancer prevention agent, calming, antiviral, anticancer, and cardiovascular problems. Quercetin is utilized to treat arthritis, allergies, inflammation, cancer, and cardiovascular problems²⁴.

Quercetin is also used to minimise oedema, eradicate cancerous cells, regulate blood sugar, and avert cardiac problems.

Some of the foods that contain Quercetin include onions, broccoli, berries, grapes, cherries, citrus fruits, apples, parsley, sage, and tea¹³.

3 Quercetin And Structure – Activity Relationship:

The structure-activity relationship (SAR) is the correlation between a molecule's chemical structure and biological activity. The SAR examination can determine the substance that causes a natural impact on an organic entity. By altering its chemical structure, this makes it possible to alter the effect or potency of a bioactive compound²⁵.

Here are some findings on the SAR of Quercetin:- Cancer Putrefaction Component Alpha inhibitory movement. Quercetin and its fundamentally comparative flavonoid have better inhibitory movement when their compound potential is more sure and their electrophilicity record is more negative.

Antioxidant property: Quercetin's polyphenolic underlying parts give it areas of strength for its properties. Cells are shielded from H2O2-induced calcium deregulation and oxidative stress by these properties.

Structural planarity: The presence of a twofold bond in ring A of Quercetin is significant for keeping up with its primary planarity. This impacts its limiting mode, the principal communication force, and the control step in electrochemistry tests.

Numerous fruits and vegetables contain Quercetin, such as: Citrus organic products, which include tea, red wine, olive oil, grapes, onions, parsley, sage, apples, and dim cherries.

Quercetin is likewise found in dull berries like blueberries, blackberries, and bilberries. The quantitative design-action relationship studies were done utilising the AI QSAR Python bundle, Py QSAR. From the quantitative construction action relationship, it tends to be perceived that substance potential ought to be more sure and electrophilicity list be more negative for better cancer rot component alpha inhibitory action for Quercetin, and it's basically similar flavonoids³⁶.

4 Quercetin As An Anti Diabetic Compounds:

Quercetin is a flavonoid that might have antidiabetic properties. It might work by: Animating glucose take-up: Quercetin might animate cell glucose take-up and lessen hyperglycemia. Further developing insulin awareness: Quercetin might further develop insulin awareness, glucose digestion, and insulin emission. Impeding insulin flagging: Quercetin may hinder insulin signalling in target tissues in the periphery.

Other potential anti diabetic effects of Quercetin include: lessening oxidative pressure; further developing insulin resistance; going about as a promising specialist against the pathophysiological difficulties of diabetes; and having anti-hyperglycemic action²⁶.

While there is a lot of in vitro and in vivo confirmation supporting the counter-diabetic capacity of Quercetin, its suitability in diabetic human subjects isn't permanently established²⁷.

As shown in Fig. 2, Quercetin is an aglycone that is frequently found in leafy foods as glycol conjugates, such as glycoside, glucuronide, rutinoside, and so forth. ³⁷. The steadiness of Quercetin is affected by oxygen focus, pH esteem, temperature, the centralization of different cell reinforcements, and the presence of metal particles. As a result, its chemical composition changes during food processing and storage³⁸. After being absorbed in the gut, quercetin undergoes phase II metabolism, conjugates into derivatives that are methylated, sulfated, and glucuronidated, and is ultimately eliminated through bile, urine, and faeces³⁹.

4.1 Quercetin as an anti-diabetic agent via the ampk pathway:

Your clinical supplier can give direction on what is best for your circumstances. This data doesn't comprise clinical exhortation or analysis.

Quercetin is a characteristic flavonoid found in natural products, vegetables, and restorative plants. As a potential treatment for type 2 diabetes, it looks promising. Quercetin enacts the 5' adenosine monophosphate-initiated protein kinase (AMPK) pathway, which can assist with amending insulin obstruction²⁸.

4.2 Quercetin as an anti hyperglycemic agent:

Your clinical supplier can give direction on what is best for your circumstances. This data doesn't comprise clinical advice or a diagnosis. As indicated by certain investigations, Quercetin is a promising anti-hyperglycemic agent. It might assist with overseeing type 2 diabetes and its inconveniences. Quercetin stimulates cellular glucose take-up and diminishes hyperglycemia. It directs key flagging pathways associated with glucose digestion. Lessens oxidative pressure and further develops insulin obstruction. Go about as a promising specialist against the patho physiological entanglements of diabetes.

4.3 Quercetin as an anti-radiogenic and anti-hypolipidemic agent:

Adipocytes are dysfunctional in metabolic disease similar to fatness, NAFLD, and T2DM. Consequently, pharmacological mediations have significance in forestalling the separation of adipocytes and animating lipid take-up. We, accordingly, examined the effects of 3T3-L1 adipocytes on adipocyte separation and lipid uptake of arbutin (ARB), purpurin (PUR), quercetin (QR), and pterostilbene (PTS). Additionally, in silico docking studies were carried out to investigate the relationships between ARB, PUR, QR, and PTS and the thioesterase (TE) and beta-ketoacyl reductase (KR) domains of unsaturated fat synthase (FAS) compounds. Mature 3T3-L1 adipocytes were utilized to examine the counter-adipogenic impact of chosen pharmacological specialists by oil red-orange staining and in vitro unsaturated fat take-up examination²⁹.

4.4 Quercetin as anti-inflammatory and antioxidant agent:

Quercetin might forestall aggravation by expanding the movement of peroxisome proliferator-enacted receptor c (PPARγ). This disturbs the transcriptional enactment of incendiary attributes by activator protein-1 (AP-1) or NF-κB. Together, they stop TNF from starting inflammatory cascades³⁰. Quercetin cell reinforcement action basically appears through its impact on glutathione (GSH), enzymatic action, signal transduction pathways, and responsive oxygen species (ROS). By maintaining oxidative balance, Quercetin exhibits strong antioxidant activity³¹. Quercetin may also stabilise the cells in the body that release histamine, making it an anti-inflammatory and anti-histamine. Blueberries are particularly strong in light of the fact that they contain the cancer prevention agent known as Quercetin, which has solid mitigating properties³².

5 DISCUSSIONS:

Quercetin is most commonly used to treat heart and blood vessel problems and prevent cancer. It's also used to treat bladder infections, diabetes, and arthritis, though most of these applications lack strong scientific        support³³.

Your clinical supplier can give direction on what is best for your circumstances. This data doesn't comprise a clinical exhortation or conclusion. Quercetin is a characteristic flavonoid tracked down in leafy foods. It has been utilized as a dietary enhancement to safeguard against illnesses like metabolic and digestive issues. It likewise has mitigating, anti-viral, and hostile to disease properties³⁵. Quercetin is generally utilized for conditions of the heart and veins as well as to prevent the growth of cancer. It is likewise utilized for joint inflammation, bladder contamination, and diabetes. Be that as it may, there are serious areas of strength with no proof to help the vast majority of these purposes³⁴. Quercetin has usually higher bioavailability than different phytochemicals. Its fundamental sources include: grapes, berries, cherries, apples, citrus organic products, onions, buckwheat, kale, tomatoes, red wine, and dark tea. Contingent upon utilisation of vegetables, tea, and organic products, Quercetin admission changes from 50 to 800 mg each day.

Fig. no. 2: uses and source of Quercetin

6. CONCLUSION:

Hyperglycemia, a metabolic disease called diabetes mellitus, can cause death as well as a number of chronic issues. Anti-diabetic medications carry a significant risk when treating insulin-resistant type 2 diabetes. Quercetin is one of the natural compounds that have been investigated as potential substitutes for anti-diabetic medications.

Natural flavonoid like Quercetin, which can be found in fruits and vegetables, have the ability to regulate the body's metabolism of lipids and glucose, thereby acting as an anti-hyperglycemia agent. With regard to the breakdown of fat or glucose, quercetin can inhibit mitochondrial activity and activate the AMPK pathway, which then interacts with several other metabolic pathways. Quercetin not only reduces the risk of diabetes but also reduces the generation of reactive oxygen species, which has anti-inflammatory and antioxidant properties.

There are still numerous Quercetin mechanisms that are unknown. Nonetheless, Quercetin exhibits significant promise as an oral anti-diabetic medication based on the mechanisms that have been suggested. However, Quercetin has certain disadvantages, including poor absorption and high toxicity when consumed unrefined. Future research on Quercetin is required in order to develop a Quercetin compound with good anti-diabetic potential as well as good pharmacokinetics. This review should focus on exploring derivatives of Quercetin or modifying its structure.

7 REFERENCES:

1. Nitin D Deore, Shruti Gupta, Birendra Shrivastav, C. D. Upasni, Kishori G Apte, Shaikh A. M. Evidence based Evaluation of Antidiabetic Potential of Yesaka on Streptozotocin Diabetic Rats. Research J. Pharm. and Tech. 2018; 11(11): 4965-4970.

2. Porkodi Karthikeyan, M.V. Dass Prakash, Pavithra Devi Sendurapandi, Kalaiselvi Periandavan. Assessment of the antidiabetic potential of Gymnemic acid as α-amylase and α-Glucosidase inhibitor using invitro and insilico tools. Research Journal of Pharmacy and Technology. 2021; 14(9): 4755-9.

3. Tabatabaei-Malazy O, Ramezani A, Atlasi R, Larijani B, Abdollahi M. Scientometric study of academic publications on antioxidative herbal medicines in type 2 diabetes mellitus. Journal of diabetes and metabolic disorders. 2016; Dec; 15: 1-8. doi:10.1186/s40200-016-0273

4. Bhat KP, Balasubramaniyan V, Vaillant B, Ezhilarasan R, Hummelink K, Hollingsworth F, Wani K, Heathcock L, James JD, Goodman LD, Conroy S. Mesenchymal differentiation mediated by NF-κB promotes radiation resistance in glioblastoma. Cancer cell. 2013; Sep 9; 24(3): 331-46.doi:10.1016/j.ccr.2013.08.001

5. Van Meter AR, Youngstrom EA, Findling RL. Cyclothymic disorder: a critical review. Clinical Psychology Review. 2012; 1; 32(4): 229-43.doi:10.1016/j.cpr.2012.02.001

6. Maqbool F, Mostafalou S, Bahadar H, Abdollahi M. Review of endocrine disorders associated with environmental toxicants and possible involved mechanisms. Life Sciences. 2016; Jan 15; 145: 265-73. doi:10.1016/j.lfs.2015.10.022

7. Daisy Sharma, Manash Pratim Sarma, Chandana Choudhury Barua, Radali Duarah, Pameena Narzary. In-vivo and In- vitro Antidiabetic potential of Musa balbisiana colla and its different parts. Research Journal of Pharmacy and Technology. 2023; 16(12): 5667-0.

8. Supriya C. Patil, Suresh G. Killedar, Harinath N. More, Ashok A. Hajare, A. S. Manjappa. In Silico Exploration of Phytoconstituents and Identification of Hits Against α-Amylase for Antidiabetic Potential. Research Journal of Pharmacy and Technology. 2024; 17(1): 419-6.

9. Wadhwa K, Kadian V, Puri V, Bhardwaj BY, Sharma A, Pahwa R, Rao R, Gupta M, Singh I. New insights into quercetin nanoformulations for topical delivery. Phytomedicine Plus. 2022; May 1; 2(2): 100257. DOI:10.1016/j.phyplu.2022.100257

10. Raj, B, Choudhary, M.,Budhwar, V. Antidiabetic activity of Psidium guajava leaf: An update rewie. Neuroquantology20(19), 2170-2177.DOI: 10.48047/nq.2022.20.19.NQ99182

11. K. Keerthana, G. Jothi. Determination of In vitro antidiabetic potential of Aqueous and Ethanol extracts and isolated fraction of Zanthoxylum armatum DC stem bark. Research J. Pharm. and Tech. 2020; 13(8): 3681-3684.

12. Nigam V, Sodhi JS. Some medicinal plants with antioxidant activity: a review. Int J Pharm Biol Sci. 2014; 4: 173-8. doi:10.4103/0973-7847.194044.

13. Anupam K. Sachan, Ch. V. Rao, Nikhil K. Sachan. Determination of Antidiabetic Potential in Crude Extract of Caesalpinia bonducella Wild on normal and Streptozotocin Induced Diabetic Rats. Research J. Pharm. and Tech. 2020; 13(2): 857-861.

14. Salvamani S, Gunasekaran B, Shaharuddin NA, Ahmad SA, Shukor MY. Antiartherosclerotic effects of plant flavonoids. BioMed Research International. 2014; 2014(1): 480258.  https://doi.org/10.1155/2014/480258

15. Bushra Sultana BS, Farooq Anwar FA. Flavonols (kaempeferol, quercetin, myricetin) contents of selected fruits, vegetables and medicinal plants. doi:10.1016/j.foodchem.2007.11.053

16. S, P., and K.S, M. (2014). Antioxidant and drug metabolism. Free Radicals and Antioxidants, 4(1), 1–2. https://doi.org/10.5530/fra.2014.1.1

17. Pham-Huy, Lien Ai et al. “Free radicals, antioxidants in disease and health.” International journal of biomedical science : IJBS vol. 4,2 (2008): 89-96.

18. Blokhina, Olga et al. Antioxidants, oxidative damage and oxygen deprivation stress: a review. Annals of Botany.  2003; 91: 179-94. doi:10.1093/aob/mcf118

19. Sandhar, H. K., Kumar, B., Prasher, S., Tiwari, P., Salhan, M., and Sharma, P. A review of phytochemistry and pharmacology of flavonoids. Internationale Pharmaceutica Sciencia. 2011; 1(1): 25-41.

20. Agrawal, A. D. Pharmacological activities of flavonoids: a review. International Journal of Pharmaceutical Sciences and Nanotechnology (IJPSN). 2011: 1394-1398. DOI:10.37285/ijpsn.2011.4.2.3

21. Pal, Dilip Kumar and Verma, Preet. Flavonoids: A powerful and abundant source of antioxidants. Int J Pharm Pharm Sci. 2013; 5(3): 95-98.

22. Lakhanpal, P., and Rai, D. K. Quercetin: a versatile flavonoid. Internet Journal of Medical Update. 2007; 2(2): 22-37. DOI: 10.4314/ijmu.v2i2.39851

23. Anand David, Alexander Victor et al. Overviews of Biological Importance of Quercetin: A Bioactive Flavonoid. Pharmacognosy Reviews. 2016; 10: 84-89. doi:10.4103/0973-7847.194044

24. Rauf, Abdur et al. Anticancer potential of quercetin: A comprehensive review. Phytotherapy Research.  PTR. 2018; 32(11): 2109-2130. doi:10.1002/ptr.6155

25. Al-Ishaq, Raghad Khalid et al. Flavonoids and Their Anti-Diabetic Effects: Cellular Mechanisms and Effects to Improve Blood Sugar Levels. Biomolecules. 2019; 9(9): 430 doi:10.3390/biom9090430

26. Eid, Hoda M, and Pierre S Haddad. The Antidiabetic Potential of Quercetin: Underlying Mechanisms. Current Medicinal Chemistry.  2017; 24(4): 355-364. doi:10.2174/0929867323666160909153707

27. Suman Saha, Amit Roy, Sanjib Bahadur, Ananta Choudhury. Fabrication and in-vitro evaluation of liposomal quercetin and its optimization. Research J. Pharm. and Tech. 2018; 11(1): 61-64.

28. Eid, Hoda M et al. The molecular basis of the antidiabetic action of quercetin in cultured skeletal muscle cells and hepatocytes. Pharmacognosy Magazine. 2015; 11(41): 74-81. doi:10.4103/0973-1296.149708

29. Ganjayi, Muni Swamy et al. Quercetin-3-O-rutinoside from Moringa oleifera Downregulates Adipogenesis and Lipid Accumulation and Improves Glucose Uptake by Activation of AMPK/Glut-4 in 3T3-L1 Cells. Revista brasileira de farmacognosia: Orgao oficial da Sociedade Brasileira de Farmacognosia.  2023; 33(2): 334-343. doi:10.1007/s43450-022-00352-9

30. Li, Yao et al. Quercetin, Inflammation and Immunity. Nutrients. 2016; 8(3):  167 doi:10.3390/nu8030167

31. Boots, Agnes W et al. Health effects of quercetin: from antioxidant to nutraceutical. European Journal of Pharmacology. 2008; 585(2-3): 325-37. doi:10.1016/j.ejphar.2008.03.008

32. Xu, Dong et al. “Antioxidant Activities of Quercetin and Its Complexes for Medicinal Application.” Molecules (Basel, Switzerland) vol. 24,6 1123. 21 Mar. 2019, doi:10.3390/molecules24061123

33. Durga. M, Nathiya. S, Devasena.T. A Simple Protocol for the Isolation of Quercetin from Trigonella foenum-graecum L. Leaves and Antioxidant analysis for Combating Toxicity. Research J. Pharm. and Tech. 2017; 10(7): 2047-2052.

34. Dinesh Kumar V., Priya Ranjan Prasad Verma. Development of a poly (ε Caprolactone) based nanoparticles for oral delivery of Quercetin. Research J. Pharm. and Tech. 2015; 8(7): 836-840.

35. Waheed Janabi, Alhamzah Hasan et al. “Flavonoid-rich foods (FRF): A promising nutraceutical approach against lifespan-shortening diseases.” Iranian Journal of Basic Medical Sciences. 2020; 23(2): 140-153. doi:10.22038/IJBMS.2019.35125.8353

36. Geoffrey, A. B., Prasana, J. C., and Muthu, S. Structure-Activity relationship of Quercetin and its Tumor Necrosis Factor Alpha inhibition activity by computational and machine learning methods. Materials Today: Proceedings. 2022;; 50: 2609-2614. DOI:10.1016/j.matpr.2020.07.464

37. Dhanya, R. Quercetin for managing type 2 diabetes and its complications, an insight into multitarget therapy. Biomedicine and pharmacotherapy = Biomedecine and Pharmacotherapie. 2022; 146: 112560. doi:10.1016/j.biopha.2021.112560

38. Cai, Kuihua, and Anders Bennick. Effect of salivary proteins on the transport of tannin and quercetin across intestinal epithelial cells in culture. Biochemical Pharmacology. 2006; 72(8): 974-80. doi:10.1016/j.bcp.2006.06.026

39. Hai, Y., Zhang, Y., Liang, Y., Ma, X., Qi, X., Xiao, J.  and Yue, T. Advance on the absorption, metabolism, and efficacy exertion of quercetin and its important derivatives: absorption, metabolism and function of quercetin. Food Frontiers, 2020; 1(4): 420-434. DOI:10.1002/fft2.50

Received on 19.09.2024      Revised on 13.03.2025

Accepted on 16.07.2025 Published on 01.12.2025

Available online from December 06, 2025

Research J. Pharmacy and Technology. 2025;18(12):6125-6130.

DOI: 10.52711/0974-360X.2025.00885

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